Neuropathological stageing of Alzheimer-related changes - Braak, H.; Braak, E. (Acta Neuropathol, 1991)

Age, neurofibrillary changes, A beta-amyloid and the onset of Alzheimer’s disease - Braak, H.; Braak, E.; Bohl, J.; Reintjes, R. (Neurosci Lett, 1996)

Staging of Alzheimer-related cortical destruction - Braak, H.; Braak, E.; Bohl, J. (Eur Neurol, 1993)

The secretases: enzymes with therapeutic potential in Alzheimer disease - De Strooper, B.; Vassar, R.; Golde, T. (Nat Rev Neurol, 2010)

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease - Strittmatter, W. J.; Weisgraber, K. H.; Huang, D. Y.; Dong, L. M.; Salvesen, G. S.; Pericak-Vance, M.; Schmechel, D.; Saunders, A. M.; Goldgaber, D.; Roses, A. D. (Proc Natl Acad Sci U S A, 1993)

A genome-wide association study for late-onset Alzheimer’s disease using DNA pooling - Abraham, R.; Moskvina, V.; Sims, R.; Hollingworth, P.; Morgan, A.; Georgieva, L.; Dowzell, K.; Cichon, S.; Hillmer, A. M.; O’Donovan, M. C.; Williams, J.; Owen, M. J.; et al. (BMC Med Genomics, 2008)

Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease - Beecham, G. W.; Martin, E. R.; Li, Y. J.; Slifer, M. A.; Gilbert, J. R.; Haines, J. L.; Pericak-Vance, M. A. (Am J Hum Genet, 2009)

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer’s disease, and shows evidence for additional susceptibility genes - Harold, D.; Abraham, R.; Hollingworth, P.; Sims, R.; Gerrish, A.; Hamshere, M.; Singh Pahwa, J.; Moskvina, V.; Dowzell, K.; Williams, A.; Jones, N.; Thomas, C.; et al. (Nat Genet, 2009)

Mouse models of Alzheimer’s disease - Hall, A. M.; Roberson, E. D. (Brain Res Bull, 2012)

Single App knock-in mouse models of Alzheimer’s disease - Saito, T.; Matsuba, Y.; Mihira, N.; Takano, J.; Nilsson, P.; Itohara, S.; Iwata, N.; Saido, T. C. (Nat Neurosci, 2014)

Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice - Krstic, D.; Madhusudan, A.; Doehner, J.; Vogel, P.; Notter, T.; Imhof, C.; Manalastas, A.; Hilfiker, M.; Pfister, S.; Schwerdel, C.; Riether, C.; Meyer, U.; et al. (J Neuroinflammation, 2012)

Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice - Sheng, J. G.; Bora, S. H.; Xu, G.; Borchelt, D. R.; Price, D. L.; Koliatsos, V. E. (Neurobiol Dis, 2003)

Alzheimer’s disease and Notch signaling - Woo, H. N.; Park, J. S.; Gwon, A. R.; Arumugam, T. V.; Jo, D. G. (Biochem Biophys Res Commun, 2009)

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain - Schroeter, E. H.; Kisslinger, J. A.; Kopan, R. (Nature, 1998)

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE - Brou, C.; Logeat, F.; Gupta, N.; Bessia, C.; LeBail, O.; Doedens, J. R.; Cumano, A.; Roux, P.; Black, R. A.; Israel, A. (Mol Cell, 2000)

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain - De Strooper, B.; Annaert, W.; Cupers, P.; Saftig, P.; Craessaerts, K.; Mumm, J. S.; Schroeter, E. H.; Schrijvers, V.; Wolfe, M. S.; Ray, W. J.; Goate, A.; Kopan, R. (Nature, 1999)

The canonical Notch signaling pathway: unfolding the activation mechanism - Kopan, R.; Ilagan, M. X. G. (Cell, 2009)

Noncanonical notch function in motor axon guidance is mediated by Rac GTPase and the GEF1 domain of trio - Song, J. K.; Giniger, E. (Dev Dyn, 2011)

The Notch signalling system: recent insights into the complexity of a conserved pathway - Guruharsha, K. G.; Kankel, M. W.; Artavanis-Tsakonas, S. (Nat Rev Genet, 2012)

Notch signaling in the brain: in good and bad times - Alberi, L.; Hoey, S. E.; Brai, E.; Scotti, A. L.; Marathe, S. (Ageing Res Rev, 2013)

Notch1 and its ligands Delta-like and Jagged are expressed and active in distinct cell populations in the postnatal mouse brain - Stump, G.; Durrer, A.; Klein, A. L.; Lutolf, S.; Suter, U.; Taylor, V. (Mech Dev, 2002)

Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks - Alberi, L.; Liu, S.; Wang, Y.; Badie, R.; Smith-Hicks, C.; Wu, J.; Pierfelice, T. J.; Abazyan, B.; Mattson, M. P.; Kuhl, D.; Pletnikov, M.; Worley, P. F.; et al. (Neuron, 2011)

Involvement of Notch signaling in hippocampal synaptic plasticity - Wang, Y.; Chan, S. L.; Miele, L.; Yao, P. J.; Mackes, J.; Ingram, D. K.; Mattson, M. P.; Furukawa, K. (Proc Natl Acad Sci U S A, 2004)

Learning and memory deficits in Notch mutant mice - Costa, R. M.; Honjo, T.; Silva, A. J. (Curr Biol, 2003)

Notch1 activity in the olfactory bulb is odour-dependent and contributes to olfactory behaviour - Brai, E.; Marathe, S.; Zentilin, L.; Giacca, M.; Nimpf, J.; Kretz, R.; Scotti, A.; Alberi, L. (Eur J Neurosci, 2014)

Mechanisms of olfactory dysfunction in aging and neurodegenerative disorders - Kovács, T. (Ageing Res Rev, 2004)

Quintessential risk factors: their role in promoting cognitive dysfunction and Alzheimer’s disease - Daulatzai, M. A. (Neurochem Res, 2012)

Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke - Arumugam, T. V.; Chan, S. L.; Jo, D. G.; Yilmaz, G.; Tang, S. C.; Cheng, A.; Gleichmann, M.; Okun, E.; Dixit, V. D.; Chigurupati, S.; Mughal, M. R.; Ouyang, X.; et al. (Nat Med, 2006)

Neonatal stroke in mice causes long-term changes in neuronal Notch-2 expression that may contribute to prolonged injury - Alberi, L.; Chi, Z.; Kadam, S. D.; Mulholland, J. D.; Dawson, V. L.; Gaiano, N.; Comi, A. M. (Stroke, 2010)

Marathe S, Liu S, Brai E, Kaczarowski M, Alberi L. Notch signaling in response to excitotoxicity induces neurodegeneration via erroneous cell cycle reentry. Cell Death Differ. 2015. doi:http://dx.doi.org/10.1038/cdd.2015.23. Accessed 27 Mar 2015.

Notch activation enhances the microglia-mediated inflammatory response associated with focal cerebral ischemia - Wei, Z.; Chigurupati, S.; Arumugam, T. V.; Jo, D. G.; Li, H.; Chan, S. L. (Stroke, 2011)

Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease - Berezovska, O.; Xia, M. Q.; Hyman, B. T. (J Neuropathol Exp Neurol, 1998)

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production - Moehlmann, T.; Winkler, E.; Xia, X.; Edbauer, D.; Murrell, J.; Capell, A.; Kaether, C.; Zheng, H.; Ghetti, B.; Haass, C.; Steiner, H. (Proc Natl Acad Sci U S A, 2002)

Activation of the Notch pathway in Down syndrome: cross-talk of Notch and APP - Fischer, D. F.; van Dijk, R.; Sluijs, J. A.; Nair, S. M.; Racchi, M.; Levelt, C. N.; van Leeuwen, F. W.; Hol, E. M. (Faseb J, 2005)

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1 - Okochi, M.; Steiner, H.; Fukumori, A.; Tanii, H.; Tomita, T.; Tanaka, T.; Iwatsubo, T.; Kudo, T.; Takeda, M.; Haass, C. (EMBO J, 2002)

Lessons from a failed γ-Secretase Alzheimer trial - Strooper, B. D. (Cell, 2014)

CSF Presenilin-1 complexes are increased in Alzheimer’s disease - García-Ayllón, M. S.; Campanari, M. L.; Brinkmalm, G.; Rábano, A.; Alom, J.; Saura, C. A.; Andreasen, N.; Blennow, K.; Sáez-Valero, J. (Acta Neuropathol Commun, 2013)

Notch signaling modulates the activation of microglial cells - Grandbarbe, L.; Michelucci, A.; Heurtaux, T.; Hemmer, K.; Morga, E.; Heuschling, P. (Glia, 2007)

Paired helical filaments from Alzheimer disease patients contain cytoskeletal components - Perry, G.; Rizzuto, N.; Autilio-Gambetti, L.; Gambetti, P. (Proc Natl Acad Sci U S A, 1985)

Establishing the proteome of normal human cerebrospinal fluid - Schutzer, S. E.; Liu, T.; Natelson, B. H.; Angel, T. E.; Schepmoes, A. A.; Purvine, S. O.; Hixson, K. K.; Lipton, M. S.; Camp, D. G. I. I.; Coyle, P. K.; Smith, R. D.; Bergquist, J. (PLoS ONE, 2010)

Extracting β-amyloid from Alzheimer’s disease - Dries, D. R.; Yu, G.; Herz, J. (PNAS, 2012)

Trans-synaptic spread of tau pathology in vivo - Liu, L.; Drouet, V.; Wu, J. W.; Witter, M. P.; Small, S. A.; Clelland, C.; Duff, K. (PLoS ONE, 2012)

Notch steers Drosophila ISNb motor axons by regulating the Abl signaling pathway - Crowner, D.; Le Gall, M.; Gates, M. A.; Giniger, E. (Curr Biol, 2003)

Microtubule stabilizing effect of notch activation in primary cortical neurons - Ferrari-Toninelli, G.; Bonini, S. A.; Bettinsoli, P.; Uberti, D.; Memo, M. (Neuroscience, 2008)

Nuclear Notch1 signaling and the regulation of dendritic development - Redmond, L.; Oh, S. R.; Hicks, C.; Weinmaster, G.; Ghosh, A. (Nat Neurosci, 2000)

Contact-dependent inhibition of cortical neurite growth mediated by notch signaling - Sestan, N.; Artavanis-Tsakonas, S.; Rakic, P. (Science, 1999)

Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration - Liou, Y. C.; Sun, A.; Ryo, A.; Zhou, X. Z.; Yu, Z. X.; Huang, H. K.; Uchida, T.; Bronson, R.; Bing, G.; Li, X.; Hunter, T.; Lu, K. P. (Nature, 2003)

The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer’s disease - Blair, L. J.; Baker, J. D.; Sabbagh, J. J.; Dickey, C. A. (J Neurochem, 2015)

The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer - Rustighi, A.; Tiberi, L.; Soldano, A.; Napoli, M.; Nuciforo, P.; Rosato, A.; Kaplan, F.; Capobianco, A.; Pece, S.; Di Fiore, P. P.; Del Sal, G. (Nat Cell Biol, 2009)

Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast - Rustighi, A.; Zannini, A.; Tiberi, L.; Sommaggio, R.; Piazza, S.; Sorrentino, G.; Nuzzo, S.; Tuscano, A.; Eterno, V.; Benvenuti, F.; Santarpia, L.; Aifantis, I.; et al. (EMBO Mol Med, 2014)

Notch in memories: points to remember - Marathe, S.; Alberi, L. (Hippocampus, 2015)

Brai E, Marathe S, Astori S, Fredj NB, Perry E, Lamy C, Scotti A, Alberi L. Notch1 regulates hippocampal plasticity through interaction with the reelin pathway, glutamatergic transmission and CREB signaling. Front Cell Neurosci. 2015; 9. doi:http://dx.doi.org/10.3389/fncel.2015.00447. Accessed 05 Feb 2016.

Extrusion of misfolded and aggregated proteins – a protective strategy of aging neurons? - Doehner, J.; Genoud, C.; Imhof, C.; Krstic, D.; Knuesel, I. (Eur J NeuroSci, 2012)

Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer’s disease - Xiang, Y.; Bu, X. L.; Liu, Y. H.; Zhu, C.; Shen, L. L.; Jiao, S. S.; Zhu, X. Y.; Giunta, B.; Tan, J.; Song, W. H.; Zhou, H. D.; Zhou, X. F.; et al. (Acta Neuropathol, 2015)

Jagged1 regulates the activation of astrocytes via modulation of NFkappaB and JAK/STAT/SOCS pathways - Morga, E.; Mouad-Amazzal, L.; Felten, P.; Heurtaux, T.; Moro, M.; Michelucci, A.; Gabel, S.; Grandbarbe, L.; Heuschling, P. (Glia, 2009)

Expression of Notch-1 receptor and its ligands Jagged-1 and Delta-1 in amoeboid microglia in postnatal rat brain and murine BV-2 cells - Cao, Q.; Lu, J.; Kaur, C.; Sivakumar, V.; Li, F.; Cheah, P. S.; Dheen, S. T.; Ling, E. A. (Glia, 2008)

DEcreased beta-amyloid1-42 and increased tau levels in cerebrospinal fluid of patients with alzheimer disease - Sunderland, T.; Linker, G.; Mirza, N. (JAMA, 2003)

Lopez-Font I, Cuchillo-Ibañez I, Sogorb-Esteve A, García-Ayllón MS, Sáez-Valero J. Transmembrane amyloid-related proteins in CSF as potential biomarkers for Alzheimer’s disease. Front Neurol. 2015; 125. doi:http://dx.doi.org/10.3389/fneur.2015.00125. Accessed 04 Feb 2016.

Extracellular, circulating proteasomes and ubiquitin – Incidence and relevance - Sixt, S. U.; Dahlmann, B. (Biochimica et Biophysica Acta (BBA) - Mol Basis Disease, 2008)

Circulating extracellular proteasome in the cerebrospinal fluid: a study on concentration and proteolytic activity - Mueller, O.; Anlasik, T.; Wiedemann, J.; Thomassen, J.; Wohlschlaeger, J.; Hagel, V.; Keyvani, K.; Schwieger, I.; Dahlmann, B.; Sure, U.; Sixt, S. U. (J Mol Neurosci, 2011)

Secretion of the Notch-1 Abeta-like peptide during Notch signaling - Okochi, M.; Fukumori, A.; Jiang, J.; Itoh, N.; Kimura, R.; Steiner, H.; Haass, C.; Tagami, S.; Takeda, M. (J Biol Chem, 2006)

Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer’s disease - Deane, R.; Bell, R.; Sagare, A.; Zlokovic, B. (CNS Neurol Disord Drug Targets, 2009)

Clearance of amyloid-beta by circulating lipoprotein receptors - Sagare, A.; Deane, R.; Bell, R. D.; Johnson, B.; Hamm, K.; Pendu, R.; Marky, A.; Lenting, P. J.; Wu, Z.; Zarcone, T.; Goate, A.; Mayo, K.; et al. (Nat Med, 2007)

Amyloid-degrading enzymes as therapeutic targets in Alzheimers disease - Nalivaeva, N.; Fisk, L.; Belyaev, N.; Turner, A. (Curr Alzheimer Res, 2008)

Notch signaling proteins HES-1 and Hey-1 bind to insulin degrading enzyme (IDE) proximal promoter and repress its transcription and activity: implications for cellular Abeta metabolism - Leal, M. C.; Surace, E. I.; Holgado, M. P.; Ferrari, C. C.; Tarelli, R.; Pitossi, F.; Wisniewski, T.; Castano, E. M.; Morelli, L. (Biochim Biophys Acta, 2012)

Hepatic notch signaling correlates with insulin resistance and nonalcoholic fatty liver disease - Valenti, L.; Mendoza, R. M.; Rametta, R.; Maggioni, M.; Kitajewski, C.; Shawber, C. J.; Pajvani, U. B. (Diabetes, 2013)

Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling - Kang, D. E.; Yoon, I. S.; Repetto, E.; Busse, T.; Yermian, N.; Ie, L.; Koo, E. H. (J Biol Chem, 2005)

Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals - McKenzie, G.; Ward, G.; Stallwood, Y.; Briend, E.; Papadia, S.; Lennard, A.; Turner, M.; Champion, B.; Hardingham, G. E. (BMC Cell Biol, 2006)

Reciprocal regulation of Notch and PI3k/Akt signalling in T-ALL cells in vitro - Calzavara, E.; Chiaramonte, R.; Cesana, D.; Basile, A.; Sherbet, G. V.; Comi, P. (J Cell Biochem, 2008)

Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer’s disease - Ferreira, S. T.; Clarke, J. R.; Bomfim, T. R.; Felice, D.; De Felice, F. G. (Alzheimer’s Dementia J Alzheimer’s Assoc, 2014)

How does brain insulin resistance develop in Alzheimer’s disease? - De Felice, F. G.; Lourenco, M. V.; Ferreira, S. T. (Alzheimer’s Dementia J Alzheimer’s Assoc, 2014)