Cancer statistics, 2023 - Siegel, R. L.; Miller, K. D.; Wagle, N. S.; Jemal, A. (CA Cancer J Clin, 2023)

NCCN guidelines insights: non-small cell lung cancer, version 5.2018 - Ettinger, D. S.; Aisner, D. L.; Wood, D. E.; Akerley, W.; Bauman, J.; Chang, J. Y. (J Natl Compr Canc Netw, 2018)

Real-world data on prognostic factors for overall survival in EGFR mutation-positive advanced non-small cell lung cancer patients treated with first line gefitinib - Yao, Z. H.; Liao, W. Y.; Ho, C. C.; Chen, K. Y.; Shih, J. Y.; Chen, J. S. (Oncologist, 2017)

Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer - Kwak, E. L.; Bang, Y. J.; Camidge, D. R.; Shaw, A. T.; Solomon, B.; Maki, R. G. (N Engl J Med, 2010)

Association between younger age and targetable genomic alterations and prognosis in non-small-cell lung cancer - Sacher, A. G.; Dahlberg, S. E.; Heng, J.; Mach, S.; Janne, P. A.; Oxnard, G. R. (JAMA Oncol, 2016)

Crizotinib in ROS1-rearranged non-small-cell lung cancer - Shaw, A. T.; Ou, S. H.; Bang, Y. J.; Camidge, D. R.; Solomon, B. J.; Salgia, R. (N Engl J Med, 2014)

Oncogenic role of fusion-circRNAs derived from cancer-associated chromosomal translocations - Guarnerio, J.; Bezzi, M.; Jeong, J. C.; Paffenholz, S. V.; Berry, K.; Naldini, M. M. (Cell, 2016)

CircRNA: functions and properties of a novel potential biomarker for cancer - Meng, S.; Zhou, H.; Feng, Z.; Xu, Z.; Tang, Y.; Li, P. (Mol Cancer, 2017)

Diagnostic and prognostic value of circulating CircRNAs in Cancer - Wang, M.; Xie, F.; Lin, J.; Zhao, Y.; Zhang, Q.; Liao, Z.; Wei, P. (Front Med (Lausanne), 2021)

CircRNAs as promising biomarker in diagnostic and prognostic of lung cancer: an updated meta-analysis - Yang, X.; Tian, W.; Wang, S.; Ji, X.; Zhou, B. (Genomics, 2021)

Clinicopathological and prognostic significance of circRNAs in lung cancer: a systematic review and meta-analysis - Zheng, Y.; Hu, J.; Li, Y.; Hao, R.; Qi, Y. (Med (Baltim), 2021)

The PRISMA 2020 statement: an updated guideline for reporting systematic reviews - Page, M. J.; McKenzie, J. E.; Bossuyt, P. M.; Boutron, I.; Hoffmann, T. C.; Mulrow, C. D. (BMJ, 2021)

A guide to systematic review and meta-analysis of prognostic factor studies - Riley, R. D.; Moons, K. G.; Snell, K. E.; Ensor, J.; Hooft, L.; Altman, D. G. (BMJ, 2019)

Wells GA, Shea B, O’Connell D, Peterson J, Welch V, Losos M et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Accessed July 11, 2023.

Elevation of circular RNA circ_0003645 forecasts unfavorable prognosis and facilitates cell progression via miR-1179/TMEM14A pathway in non-small cell lung cancer - An, J.; Shi, H.; Zhang, N.; Song, S. (Biochem Biophys Res Commun, 2019)

Cancer cell-derived exosomal circUSP7 induces CD8 + T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC - Chen, S. W.; Zhu, S. Q.; Pei, X.; Qiu, B. Q.; Xiong, D.; Long, X.; Lin, K.; Lu, F.; Xu, J. J.; Wu, Y. B. (Mol Cancer, 2021)

Upregulation of circ_001569 predicts poor prognosis and promotes cell proliferation in non-small cell lung cancer by regulating the Wnt/β-catenin pathway - Ding, L.; Yao, W.; Lu, J.; Gong, J.; Zhang, X. (Oncol Lett, 2018)

The novel circular RNA circ-CAMK2A enhances lung adenocarcinoma metastasis by regulating the miR-615-5p/fibronectin 1 pathway - Du, J.; Zhang, G.; Qiu, H.; Yu, H.; Yuan, W. (Cell Mol Biol Lett, 2019)

Circular RNA circ_0074027 indicates a poor prognosis for NSCLC patients and modulates cell proliferation, apoptosis, and invasion via mir-185-3p mediated BRD4/MADD activation - Gao, P.; Wang, Z.; Hu, Z.; Jiao, X.; Yao, Y. (J Cell Biochem, 2020)

CircRNA circ-BANP-mediated miR-503/LARP1 signaling contributes to lung cancer progression - Han, J.; Zhao, G.; Ma, X.; Dong, Q.; Zhang, H.; Wang, Y. (Biochem Biophys Res Commun, 2018)

RNA circ-RAD23B promotes cell growth and invasion by miR-593-3p/CCND2 and miR-653-5p/TIAM1 pathways in non-small cell lung cancer - Han, W.; Wang, L.; Zhang, L.; Wang, Y.; Li, Y.; Circular (Biochem Biophys Res Commun, 2019)

RNA ATXN7 is upregulated in non-small cell lung cancer and promotes disease progression - Huang, Q.; Wang, S.; Li, X.; Yang, F.; Feng, C.; Zhong, K.; Qiu, M.; Wang, J.; Circular (Oncol Lett, 2019)

Circular RARS, promotes aerobic glycolysis of non-small-cell lung cancer by binding with LDHA - Li, H.; Huang, Q.; Guo, H.; Chen, X.; Li, X.; Qiu, M.; Circular, R. N. A. (Thorac Cancer, 2023)

Enhanced expression of circular RNA hsa_circ_000984 promotes cells proliferation and metastasis in non-small cell lung cancer by modulating Wnt/β-catenin pathway - Li, X. Y.; Liu, Y. R.; Zhou, J. H.; Li, W.; Guo, H. H.; Ma, H. P. (Eur Rev Med Pharmacol Sci, 2019)

Upregulated circular RNA circ_0016760 indicates unfavorable prognosis in NSCLC and promotes cell progression through miR-1287/GAGE1 axis - Li, Y.; Hu, J.; Li, L.; Cai, S.; Zhang, H.; Zhu, X.; Guan, G.; Dong, X. (Biochem Biophys Res Commun, 2018)

Circular RNA circ-FOXM1 facilitates cell progression as ceRNA to target PPDPF and MACC1 by sponging mir-1304-5p in non-small cell lung cancer - Liu, G.; Shi, H.; Deng, L.; Zheng, H.; Kong, W.; Wen, X.; Bi, H. (Biochem Biophys Res Commun, 2019)

Circular RNA hsa_circRNA_103809 promotes lung cancer progression via facilitating ZNF121-dependent MYC expression by sequestering miR-4302 - Liu, W.; Ma, W.; Yuan, Y.; Zhang, Y.; Sun, S. (Biochem Biophys Res Commun, 2018)

Circular RNA hsa_circ_0004689 (circSWT1) promotes NSCLC progression via the miR-370-3p/SNAIL axis by inducing cell epithelial-mesenchymal transition (EMT) - Long, X.; Wang, D. G.; Wu, Z. B.; Liao, Z. M.; Xu, J. J. (Cancer Med, 2023)

Overexpression of hsa_circ_0001715 is a potential Diagnostic and Prognostic Biomarker in Lung Adenocarcinoma - Lu, G. J.; Cui, J.; Qian, Q.; Hou, Z. B.; Xie, H. Y.; Hu, W.; Hao, K. K.; Xia, N.; Zhang, Y. (Onco Targets Ther, 2020)

Upregulation of circular RNA hsa_circ_0007534 predicts unfavorable prognosis for NSCLC and exerts oncogenic properties in vitro and in vivo - Qi, Y.; Zhang, B.; Wang, J.; Yao, M. (Gene, 2018)

Circular RNA PVT1 acts as a competing endogenous RNA for miR-497 in promoting non-small cell lung cancer progression - Qin, S.; Zhao, Y.; Lim, G.; Lin, H.; Zhang, X.; Zhang, X. (Biomed Pharmacother, 2019)

The circular RNA circPRKCI promotes Tumor Growth in Lung Adenocarcinoma - Qiu, M.; Xia, W.; Chen, R.; Wang, S.; Xu, Y.; Ma, Z.; Xu, W.; Zhang, E.; Wang, J.; Fang, T.; Hu, J.; Dong, G.; et al. (Cancer Res, 2018)

A novel circular RNA hsa_circ_0020123 exerts oncogenic properties through suppression of miR-144 in non-small cell lung cancer - Qu, D.; Yan, B.; Xin, R.; Ma, T. (Am J Cancer Res, 2018)

CiRS-7 targeting miR-7 modulates the progression of non-small cell lung cancer in a manner dependent on NF-κB signalling - Su, C.; Han, Y.; Zhang, H.; Li, Y.; Yi, L.; Wang, X. (J Cell Mol Med, 2018)

Circular RNA circ_0020123 promotes non-small cell lung cancer progression by acting as a ceRNA for mir-488-3p to regulate ADAM9 expression - Wan, J.; Hao, L.; Zheng, X.; Li, Z. (Biochem Biophys Res Commun, 2019)

CircRNA circ_0067934 silencing inhibits the proliferation, migration and invasion of NSCLC cells and correlates with unfavorable prognosis in NSCLC - Wang, J.; Li, H. (Eur Rev Med Pharmacol Sci, 2018)

Up-regulated circular RNA VANGL1 contributes to progression of non-small cell lung cancer through inhibition of miR-195 and activation of Bcl-2 - Wang, L.; Ma, H.; Kong, W.; Liu, B.; Zhang, X. (Biosci Rep, 2019)

Circular RNA circ-PRMT5 facilitates non-small cell lung cancer proliferation through upregulating EZH2 via sponging miR-377/382/498 - Wang, Y.; Li, Y.; He, H.; Wang, F. (Gene, 2019)

Circular RNA ciRS-7 correlates with advance disease and poor prognosis, and its down-regulation inhibits cells proliferation while induces cells apoptosis in non-small cell lung cancer - Yan, B.; Zhang, W.; Mao, X. W.; Jiang, L. Y. (Eur Rev Med Pharmacol Sci, 2018)

CircRNA has_circ_0001946 promotes cell growth in lung adenocarcinoma by regulating miR-135a-5p/SIRT1 axis and activating Wnt/β-catenin signaling pathway - Yao, Y.; Hua, Q.; Zhou, Y.; Shen, H. (Biomed Pharmacother, 2019)

Overexpressed CDR1as functions as an oncogene to promote the tumor progression via miR-7 in non-small-cell lung cancer - Zhang, X.; Yang, D.; Wei, Y. (Onco Targets Ther, 2018)

Circulating circular RNA hsa_circ_0023179 acts as a diagnostic biomarker for non-small-cell lung cancer detection - Zhang, Q.; Qin, S.; Peng, C.; Liu, Y.; Huang, Y.; Ju, S. (J Cancer Res Clin Oncol, 2023)

CircRNA_101237 promotes NSCLC progression via the miRNA-490-3p/MAPK1 axis - Zhang, Z. Y.; Gao, X. H.; Ma, M. Y.; Zhao, C. L.; Zhang, Y. L.; Guo, S. S. (Sci Rep, 2020)

circFADS2 regulates lung cancer cells proliferation and invasion via acting as a sponge of miR-498 - Zhao, F.; Han, Y.; Liu, Z.; Zhao, Z.; Li, Z.; Jia, K. (Biosci Rep, 2018)

Increased expression of circRNA_102231 in lung cancer and its clinical significance - Zong, L.; Sun, Q.; Zhang, H.; Chen, Z.; Deng, Y.; Li, D.; Zhang, L. (Biomed Pharmacother, 2018)

Overexpression of circ-0067934 is associated with increased cellular proliferation and the prognosis of non-small cell lung cancer - Zou, Q.; Wang, T.; Li, B.; Li, G.; Zhang, L.; Wang, B.; Sun, S. (Oncol Lett, 2018)

CircRNA hsa_circ_100395 regulates miR-1228/TCF21 pathway to inhibit lung cancer progression - Chen, D.; Ma, W.; Ke, Z.; Xie, F. (Cell Cycle, 2018)

CircSCAP interacts with SF3A3 to inhibit the malignance of non-small cell lung cancer by activating p53 signaling - Chen, D.; Zhou, H.; Cai, Z.; Cai, K.; Liu, J.; Wang, W.; Miao, H.; Li, H.; Li, R.; Li, X.; Chen, Y.; Wang, H. Y.; et al. (J Exp Clin Cancer Res, 2022)

Circular RNA cESRP1 sensitises small cell lung cancer cells to chemotherapy by sponging mir-93-5p to inhibit TGF-β signalling - Huang, W.; Yang, Y.; Wu, J.; Niu, Y.; Yao, Y.; Zhang, J. (Cell Death Differ, 2020)

Circ-ITCH correlates with less advanced tumor features as well as prolonged survival, and it inhibits cells proliferation but promotes apoptosis in non-small cell lung cancer - Li, Z.; Guo, X.; Gao, S. (Transl Cancer Res, 2019)

Circular RNA circ_0001649 acts as a prognostic biomarker and inhibits NSCLC progression via sponging mir-331-3p and miR-338-5p - Liu, T.; Song, Z.; Gai, Y. (Biochem Biophys Res Commun, 2018)

Hsa_circ_RNA_0011780 represses the proliferation and metastasis of Non-small Cell Lung Cancer by decreasing FBXW7 via Targeting miR-544a - Liu, Y.; Yang, C.; Cao, C.; Li, Q.; Jin, X.; Shi, H. (Onco Targets Ther, 2020)

RNA SMARCA5 may serve as a tumor suppressor in non-small cell lung cancer - Tong, S.; Circular (J Clin Lab Anal, 2020)

Circular RNA circCRIM1 inhibits invasion and metastasis in lung adenocarcinoma through the microRNA (miR)-182/miR-93-leukemia inhibitory factor receptor pathway - Wang, L.; Liang, Y.; Mao, Q.; Xia, W.; Chen, B.; Shen, H.; Xu, L.; Jiang, F.; Dong, G. (Cancer Sci, 2019)

Hsa_circ_0046264 up-regulated BRCA2 to suppress lung cancer through targeting hsa-miR-1245 - Yang, L.; Wang, J.; Fan, Y.; Yu, K.; Jiao, B.; Su, X. (Respir Res, 2018)

CircRNA has_circ_0006427 suppresses the progression of lung adenocarcinoma by regulating miR-6783-3p/DKK1 axis and inactivating Wnt/β-catenin signaling pathway - Yao, Y.; Hua, Q.; Zhou, Y. (Biochem Biophys Res Commun, 2019)

hsa_circ_0072309 expression profiling in non-small-cell lung carcinoma and its implications for diagnosis and prognosis - Zhou, Y.; Tong, Z.; Zhu, X.; Huang, S.; Dong, Z.; Ye, Z. (Front Surg, 2022)

Review on circular RNAs and new insights into their roles in cancer - Tang, X.; Ren, H.; Guo, M.; Qian, J.; Yang, Y.; Gu, C. (Comput Struct Biotechnol J, 2021)

Biological role and regulation of circular RNA as an emerging biomarker and potential therapeutic target for cancer - Saleem, A.; Khan, M. U.; Zahid, T.; Khurram, I.; Ghani, M. U.; Ullah, I. (Mol Biol Rep, 2024)

Emerging important roles of circRNAs in human cancer and other diseases - Huang, Y.; Zhang, C.; Xiong, J.; Ren, H. (Genes Dis, 2020)

Hotspots and development frontiers of circRNA based on bibliometric analysis - Zhang, C.; Kang, Y.; Kong, F.; Yang, Q.; Chang, D. (Noncoding RNA Res, 2022)

The emerging roles of circRNAs in cancer and oncology - Kristensen, L. S.; Jakobsen, T.; Hager, H.; Kjems, J. (Nat Rev Clin Oncol, 2022)

Circular RNAs as biomarkers for lung cancer - Sufianov, A.; Begliarzade, S.; Beilerli, A.; Liang, Y.; Ilyasova, T.; Beylerli, O. (Noncoding RNA Res, 2022)

Circular RNA in non-small cell lung carcinoma: identification of targets and New Treatment modalities - Weidle, U. H.; Birzele, F. (Cancer Genomics Proteom, 2023)

Circular RNA circSATB2 promotes progression of non-small cell lung cancer cells - Zhang, N.; Nan, A.; Chen, L.; Li, X.; Jia, Y.; Qiu, M. (Mol Cancer, 2020)

The function and clinical implication of circular RNAs in lung cancer - Ren, W.; Yuan, Y.; Peng, J.; Mutti, L.; Jiang, X. (Front Oncol, 2022)

Potential diagnostic and prognostic biomarkers of circular RNAs for Lung Cancer in China - Wang, C.; Jiang, Y.; Lei, Q.; Wu, Y.; Shao, J.; Pu, D. (Biomed Res Int, 2019)

Prognostic role of dysregulated circRNAs in patients with non-small cell lung cancer: a meta-analysis - Bao, Q.; Li, F.; Zheng, H.; Chen, S.; Song, X. (J Thorac Dis, 2020)

Diagnostic and prognostic values of circular RNAs for lung cancer: a meta-analysis - Yang, Q.; Chen, L.; Yang, L.; Huang, Y. (Postgrad Med J, 2021)

A ceRNA hypothesis: the Rosetta Stone of a hidden RNA - Salmena, L.; Poliseno, L.; Tay, Y.; Kats, L.; Pandolfi, P. (Language? Cell, 2011)

Exon-intron circular RNAs regulate transcription in the nucleus - Li, Z.; Huang, C.; Bao, C.; Chen, L.; Lin, M.; Wang, X. (Nat Struct Mol Biol, 2015)

Circular RNAs are a large class of animal RNAs with regulatory potency - Memczak, S.; Jens, M.; Elefsinioti, A.; Torti, F.; Krueger, J.; Rybak, A. (Nature, 2013)

The circular RNA ciRS-7 (Cdr1as) acts as a risk factor of hepatic microvascular invasion in hepatocellular carcinoma - Xu, L.; Zhang, M.; Zheng, X.; Yi, P.; Lan, C.; Xu, M. (J Cancer Res Clin Oncol, 2017)

ciRS-7 is a prognostic biomarker and potential gene therapy target for renal cell carcinoma - Mao, W.; Wang, K.; Xu, B.; Zhang, H.; Sun, S.; Hu, Q. (Mol Cancer, 2021)

hsa_circ_0013958: a circular RNA and potential novel biomarker for lung adenocarcinoma - Zhu, X.; Wang, X.; Wei, S. Z.; Chen, Y.; Chen, Y.; Fan, X. (FEBS J, 2017)

Lung cancer: current therapies and new targeted treatments - Hirsch, F. R.; Scagliotti, G. V.; Mulshine, J. L.; Kwon, R.; Curran, W. J.; Wu, Y. L. (Lancet, 2017)

CircRNA_100395 carried by exosomes from adipose-derived mesenchymal stem cells inhibits the malignant transformation of non-small cell lung carcinoma through the mir-141-3p-lats2 axis - Zhang, C.; Cao, J.; Lv, W.; Mou, H. (Front Cell Dev Biol, 2021)