The amyloid precursor protein: beyond amyloid - Zheng, H.; Koo, E. H. (Mol Neurodegener, 2006)

Deciphering the genetic basis of Alzheimer's disease - Selkoe, D. J.; Podlisny, M. B. (Annu Rev Genomics Hum Genet, 2002)

Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor - Passer, B.; Pellegrini, L.; Russo, C.; Siegel, R. M.; Lenardo, M. J.; Schettini, G.; Bachmann, M.; Tabaton, M.; D'Adamio, L. (J Alzheimers Dis, 2000)

A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP - Leissring, M. A.; Murphy, M. P.; Mead, T. R.; Akbari, Y.; Sugarman, M. C.; Jannatipour, M.; Anliker, B.; Muller, U.; Saftig, P.; De Strooper, B.; Wolfe, M. S.; Golde, T. E.; et al. (Proc Natl Acad Sci U S A, 2002)

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60 - Cao, X.; Sudhof, T. C. (Science, 2001)

Notch signaling: cell fate control and signal integration in development - Artavanis-Tsakonas, S.; Rand, M. D.; Lake, R. J. (Science, 1999)

Presenilins: molecular switches between proteolysis and signal transduction - Annaert, W.; De Strooper, B. (Trends Neurosci, 1999)

Fe65 stimulates proteolytic liberation of the beta-amyloid precursor protein intracellular domain - Wiley, J. C.; Smith, E. A.; Hudson, M. P.; Ladiges, W. C.; Bothwell, M. (J Biol Chem, 2007)

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein - Baek, S. H.; Ohgi, K. A.; Rose, D. W.; Koo, E. H.; Glass, C. K.; Rosenfeld, M. G. (Cell, 2002)

Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP - Pardossi-Piquard, R.; Petit, A.; Kawarai, T.; Sunyach, C.; Alves da Costa, C.; Vincent, B.; Ring, S.; D'Adamio, L.; Shen, J.; Muller, U.; St George Hyslop, P.; Checler, F. (Neuron, 2005)

Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain - Ryan, K. A.; Pimplikar, S. W. (J Cell Biol, 2005)

C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression - Kim, H. S.; Kim, E. M.; Lee, J. P.; Park, C. H.; Kim, S.; Seo, J. H.; Chang, K. A.; Yu, E.; Jeong, S. J.; Chong, Y. H.; Suh, Y. H. (Faseb J, 2003)

Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression - Zhang, Y. W.; Wang, R.; Liu, Q.; Zhang, H.; Liao, F. F.; Xu, H. (Proc Natl Acad Sci U S A, 2007)

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1 - Liu, Q.; Zerbinatti, C. V.; Zhang, J.; Hoe, H. S.; Wang, B.; Cole, S. L.; Herz, J.; Muglia, L.; Bu, G. (Neuron, 2007)

The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor - von Rotz, R. C.; Kohli, B. M.; Bosset, J.; Meier, M.; Suzuki, T.; Nitsch, R. M.; Konietzko, U. (J Cell Sci, 2004)

Swedish amyloid precursor protein mutation increases cell cycle-related proteins in vitro and in vivo - Ahn, K. W.; Joo, Y.; Choi, Y.; Kim, M.; Lee, S. H.; Cha, S. H.; Suh, Y. H.; Kim, H. S. (J Neurosci Res, 2008)

Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD) - Muller, T.; Concannon, C. G.; Ward, M. W.; Walsh, C. M.; Tirniceriu, A. L.; Tribl, F.; Kogel, D.; Prehn, J. H.; Egensperger, R. (Mol Biol Cell, 2007)

Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes - Hebert, S. S.; Serneels, L.; Tolia, A.; Craessaerts, K.; Derks, C.; Filippov, M. A.; Muller, U.; De Strooper, B. (EMBO Rep, 2006)

Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription - Waldron, E.; Isbert, S.; Kern, A.; Jaeger, S.; Martin, A. M.; Hebert, S. S.; Behl, C.; Weggen, S.; De Strooper, B.; Pietrzik, C. U. (Exp Cell Res, 2008)

The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis - Ozaki, T.; Li, Y.; Kikuchi, H.; Tomita, T.; Iwatsubo, T.; Nakagawara, A. (Biochem Biophys Res Commun, 2006)

The gamma/epsilon-Secretase-Derived APP Intracellular Domain Fragments Regulate p53 - Checler, F.; Sunyach, C.; Pardossi-Piquard, R.; Sevalle, J.; Vincent, B.; Kawarai, T.; Girardot, N.; St George-Hyslop, P.; da Costa, C. A. (Curr Alzheimer Res, 2007)

Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP) - Scheinfeld, M. H.; Roncarati, R.; Vito, P.; Lopez, P. A.; Abdallah, M.; D'Adamio, L. (J Biol Chem, 2002)

A new mathematical model for relative quantification in real-time RT-PCR - Pfaffl, M. W. (Nucleic Acids Res, 2001)

Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory - Abel, T.; Nguyen, P. V.; Barad, M.; Deuel, T. A.; Kandel, E. R.; Bourtchouladze, R. (Cell, 1997)

The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture - Cupers, P.; Orlans, I.; Craessaerts, K.; Annaert, W.; De Strooper, B. (J Neurochem, 2001)

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains - Yu, C.; Kim, S. H.; Ikeuchi, T.; Xu, H.; Gasparini, L.; Wang, R.; Sisodia, S. S. (J Biol Chem, 2001)

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch - Gu, Y.; Misonou, H.; Sato, T.; Dohmae, N.; Takio, K.; Ihara, Y. (J Biol Chem, 2001)

Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage - Minopoli, G.; Stante, M.; Napolitano, F.; Telese, F.; Aloia, L.; De Felice, M.; Di Lauro, R.; Pacelli, R.; Brunetti, A.; Zambrano, N.; Russo, T. (J Biol Chem, 2007)

Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation - Cao, X.; Sudhof, T. C. (J Biol Chem, 2004)