Opinion: Building epithelial architecture: insights from three-dimensional culture models - O'Brien, L. E.; Zegers, M. M.; Mostov, K. E. (Nat Rev Mol Cell Biol, 2002)

Capturing complex 3D tissue physiology in vitro - Griffith, L. G.; Swartz, M. A. (Nat Rev Mol Cell Biol, 2006)

Cell polarity in development and cancer - Wodarz, A.; Nathke, I. (Nat Cell Biol, 2007)

Altered growth of human colon cancer cell lines disrupted at activated Ki-ras - Shirasawa, S.; Furuse, M.; Yokoyama, N.; Sasazuki, T. (Science, 1993)

Three-dimensionally specific inhibition of DNA repair-related genes by activated KRAS in colon crypt model - Tsunoda, T.; Takashima, Y.; Fujimoto, T.; Koyanagi, M.; Yoshida, Y.; Doi, K.; Tanaka, Y.; Kuroki, M.; Sasazuki, T.; Shirasawa, S. (Neoplasia, 2010)

PDE4 inhibitors: current status - Spina, D. (Br J Pharmacol, 2008)

Challenge of human Jurkat T-cells with the adenylate cyclase activator forskolin elicits major changes in cAMP phosphodiesterase (PDE) expression by up-regulating PDE3 and inducing PDE4D1 and PDE4D2 splice variants as well as down-regulating a novel PDE4A splice variant - Erdogan, S.; Houslay, M. D. (Biochem J, 1997)

Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling - Conti, M.; Beavo, J. (Annu Rev Biochem, 2007)

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown - Houslay, M. D. (Trends Biochem Sci, 2009)

cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling - Houslay, M. D.; Baillie, G. S.; Maurice, D. H. (Circ Res, 2007)

Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5 - Li, X.; Baillie, G. S.; Houslay, M. D. (J Biol Chem, 2009)

Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2 - Bolger, G. B.; Peden, A. H.; Steele, M. R.; MacKenzie, C.; McEwan, D. G.; Wallace, D. A.; Huston, E.; Baillie, G. S.; Houslay, M. D. (J Biol Chem, 2003)

DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling - Millar, J. K.; Pickard, B. S.; Mackie, S.; James, R.; Christie, S.; Buchanan, S. R.; Malloy, M. P.; Chubb, J. E.; Huston, E.; Baillie, G. S. (Science, 2005)

Phosphodiesterase inhibitors in the treatment of inflammatory diseases - Page, C. P.; Spina, D. (Handb Exp Pharmacol, 2011)

ERK and PDE4 cooperate to induce RAF isoform switching in melanoma - Marquette, A.; Andre, J.; Bagot, M.; Bensussan, A.; Dumaz, N. (Nat Struct Mol Biol, 2011)

Cyclic nucleotide phosphodiesterases (PDE) and peptide motifs - Keravis, T.; Lugnier, C. (Curr Pharm Des, 2010)

GenePattern 2.0 - Reich, M.; Liefeld, T.; Gould, J.; Lerner, J.; Tamayo, P.; Mesirov, J. P. (Nat Genet, 2006)

A susceptibility gene set for early onset colorectal cancer that integrates diverse signaling pathways: implication for tumorigenesis - Hong, Y.; Ho, K. S.; Eu, K. W.; Cheah, P. Y. (Clin Cancer Res, 2007)

Renal epithelial cyst formation and enlargement in vitro: dependence on cAMP - Mangoo-Karim, R.; Uchic, M.; Lechene, C.; Grantham, J. J. (Proc Natl Acad Sci U S A, 1989)

Molecular perspective on tight-junction assembly and epithelial polarity - Miyoshi, J.; Takai, Y. (Adv Drug Deliv Rev, 2005)

Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages - Jin, S. L.; Lan, L.; Zoudilova, M.; Conti, M. (J Immunol, 2005)

Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner - Debnath, J.; Walker, S. J.; Brugge, J. S. (J Cell Biol, 2003)

The phosphodiesterase PDE4B limits cAMP-associated PI3K/AKT-dependent apoptosis in diffuse large B-cell lymphoma - Smith, P. G.; Wang, F.; Wilkinson, K. N.; Savage, K. J.; Klein, U.; Neuberg, D. S.; Bollag, G.; Shipp, M. A.; Aguiar, R. C. (Blood, 2005)

Organotypic models of metastasis: A three-dimensional culture mimicking the human peritoneum and omentum for the study of the early steps of ovarian cancer metastasis - Kenny, H. A.; Dogan, S.; Zillhardt, M.; Zillhardt, M.; Metra, A. K.; Yamada, S. D.; Krausz, T.; Lengyel, E. (Cancer Treat Res, 2009)

The increased expression of periostin during early stages of prostate cancer and advanced stages of cancer stroma - Tsunoda, T.; Furusato, B.; Takashima, Y.; Ravulapalli, S.; Dobi, A.; Srivastava, S.; McLeod, D. G.; Sesterhenn, I. A.; Ornstein, D. K.; Shirasawa, S. (Prostate, 2009)

Gene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancer - Fournier, M. V.; Martin, K. J.; Kenny, P. A.; Xhaja, K.; Bosch, I.; Yaswen, P.; Bissell, M. J. (Cancer Res, 2006)

Prognostic breast cancer signature identified from 3D culture model accurately predicts clinical outcome across independent datasets - Martin, K. J.; Patrick, D. R.; Bissell, M. J.; Fournier, M. V. (PLoS One, 2008)

A gene signature of 8 genes could identify the risk of recurrence and progression in Dukes' B colon cancer patients - Bandrès, E.; Malumbres, R.; Cubedo, E.; Honorato, B.; Zarate, R.; Labarga, A.; Gabisu, U.; Sola, J. J.; Garcia-Foncillas, J. (Oncol Rep, 2007)

Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis - Jaffe, A. B.; Kaji, N.; Durgan, J.; Hall, A. (J Cell Biol, 2008)

PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42 - Martin-Belmonte, F.; Gassama, A.; Datta, A.; Yu, W.; Rescher, U.; Gerke, V.; Mostov, K. (Cell, 2007)

Chemokine receptor CXCR4 expression in colorectal cancer patients increases the risk for recurrence and for poor survival - Kim, J.; Takeuchi, H.; Lam, S. T.; Turner, R. R.; Wang, H. J.; Kuo, C.; Foshag, L.; Bilchik, A. J.; Hoon, D. S. (J Clin Oncol, 2005)

The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases - Zeelenberg, I. S.; Ruuls-Van Stalle, L.; Roos, E. (Cancer Res, 2003)

Gene expression patterns that predict sensitivity to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer cell lines and human lung tumors - Balko, J. M.; Potti, A.; Saunders, C.; Stromberg, A.; Haura, E. B.; Black, E. P. (BMC Genomics, 2006)

Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases - Park, S. J.; Ahmad, F.; Philp, A.; Baar, K.; Williams, T.; Luo, H.; Ke, H.; Rehmann, H.; Taussig, R.; Brown, A. L. (Cell, 2012)

Rational combined targeting of phosphodiesterase 4B and SYK in DLBCL - Kim, S. W.; Rai, D.; McKeller, M. R.; Aguiar, R. C. (Blood, 2009)

Chronic lymphocytic leukemia and B and T cells differ in their response to cyclic nucleotide phosphodiesterase inhibitors - Meyers, J. A.; Su, D. W.; Lerner, A. (J Immunol, 2009)

Treating brain tumors with PDE4 inhibitors - Sengupta, R.; Sun, T.; Warrington, N. M.; Rubin, J. B. (Trends Pharmacol Sci, 2011)

The type IV phosphodiesterase inhibitor rolipram induces expression of the cell cycle inhibitors p21(Cip1) and p27(Kip1), resulting in growth inhibition, increased differentiation, and subsequent apoptosis of malignant A-172 glioma cells - Chen, T. C.; Wadsten, P.; Su, S.; Rawlinson, N.; Hofman, F. M.; Hill, C. K.; Schonthal, A. H. (Cancer Biol Ther, 2002)

Cyclic AMP specific phosphodiesterase activity and colon cancer cell motility - Murata, K.; Sudo, T.; Kameyama, M.; Fukuoka, H.; Muka, M.; Doki, Y.; Sasaki, Y.; Ishikawa, O.; Kimura, Y.; Imaoka, S. (Clin Exp Metastasis, 2000)

Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase - McEwan, D. G.; Brunton, V. G.; Baillie, G. S.; Leslie, N. R.; Houslay, M. D.; Frame, M. C. (Cancer Res, 2007)

Involvement of deregulated epiregulin expression in tumorigenesis in vivo through activated Ki-Ras signaling pathway in human colon cancer cells - Baba, I.; Shirasawa, S.; Iwamoto, R.; Okumura, K.; Tsunoda, T.; Nishioka, M.; Fukuyama, K.; Yamamoto, K.; Mekada, E.; Sasazuki, T. (Cancer Res, 2000)

Oncogenic KRAS Regulates miR-200c and miR-221/222 in a 3D-Specific Manner in Colorectal Cancer Cells - Tsunoda, T.; Takashima, Y.; Yoshida, Y.; Doi, K.; Tanaka, Y.; Fujimoto, T.; Machida, T.; Ota, T.; Koyanagi, M.; Kuroki, M. (Anticancer Res, 2011)

ZFAT expression in B and T lymphocytes and identification of ZFAT-regulated genes - Koyanagi, M.; Nakabayashi, K.; Fujimoto, T.; Gu, N.; Baba, I.; Takashima, Y.; Doi, K.; Harada, H.; Kato, N.; Sasazuki, T.; Shirasawa, S. (Genomics, 2008)

A comparison of normalization methods for high density oligonucleotide array data based on variance and bias - Bolstad, B. M.; Irizarry, R. A.; Astrand, M.; Speed, T. P. (Bioinformatics, 2003)

Molecular classification of cancer: class discovery and class prediction by gene expression monitoring - Golub, T. R.; Slonim, D. K.; Tamayo, P.; Huard, C.; Gaasenbeek, M.; Mesirov, J. P.; Coller, H.; Loh, M. L.; Downing, J. R.; Caligiuri, M. A. (Science, 1999)

Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers - Barber, R.; Baillie, G. S.; Bergmann, R.; Shepherd, M. C.; Sepper, R.; Houslay, M. D.; Heeke, G. V. (Am J Physiol Lung Cell Mol Physiol, 2004)

Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures - Debnath, J.; Muthuswamy, S. K.; Brugge, J. S. (Methods, 2003)

KRAS-mediated up-regulation of RRM2 expression is essential for the proliferation of colorectal cancer cell lines - Yoshida, Y.; Tsunoda, T.; Doi, K.; Tanaka, Y.; Fujimoto, T.; Machida, T.; Ota, T.; Koyanagi, M.; Takashima, Y.; Sasazuki, T. (Anticancer Res, 2011)