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Hyaluronan deficiency due to Has3 knock-out causes altered neuronal activity and seizures via reduction in brain extracellular space - Arranz, A. M.; Perkins, K. L.; Irie, F.; Lewis, D. P.; Hrabe, J.; Xiao, F.; Itano, N.; Kimata, K.; Hrabetova, S.; Yamaguchi, Y. (J Neurosci, 2014)

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Hyaluronan molecular weight distribution is associated with the risk of knee osteoarthritis progression - Band, P. A.; Heeter, J.; Wisniewski, H. G.; Liublinska, V.; Pattanayak, C. W.; Karia, R. J.; Stabler, T.; Balazs, E. A.; Kraus, V. B. (Osteoarthr Cartil, 2015)

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Exercise and injury increase chondroitin sulfate chain length and decrease hyaluronan chain length in synovial fluid - Brown, M. P.; Trumble, T. N.; Plaas, A. H.; Sandy, J. D.; Romano, M.; Hernandez, J.; Merritt, K. A. (Osteoarthr Cartil, 2007)

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Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme - Camenisch, T. D.; Spicer, A. P.; Brehm-Gibson, T.; Biesterfeldt, J.; Augustine, M. L.; Calabro, A.; Kubalak, S.; Klewer, S. E.; McDonald, J. A. (J Clin Invest, 2000)

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Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor - Chockalingam, P. S.; Sun, W.; Rivera-Bermudez, M. A.; Zeng, W.; Dufield, D. R.; Larsson, S.; Lohmander, L. S.; Flannery, C. R.; Glasson, S. S.; Georgiadis, K. E.; Morris, E. A. (Osteoarthr Cartil, 2011)

Murine hyaluronidase 2 deficiency results in extracellular hyaluronan accumulation and severe cardiopulmonary dysfunction - Chowdhury, B.; Hemming, R.; Hombach-Klonisch, S.; Flamion, B.; Triggs-Raine, B. (J Biol Chem, 2013)

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Knockdown of KIAA1199 suppresses IL-1β-induced cartilage degradation and inflammatory responses in human chondrocytes through the Wnt/β-catenin signaling pathway - Ding, Q. H.; Qi, Y. Y.; Li, X. M.; Chen, W. P.; Wang, X. H.; Ji, X. W. (Int Immunopharmacol, 2019)

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A human-specific polymorphism in the coding region of the aggrecan gene. Variable number of tandem repeats produce a range of core protein sizes in the general population - Doege, K. J.; Coulter, S. N.; Meek, L. M.; Maslen, K.; Wood, J. G. (J Biol Chem, 1997)

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Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N-acetylgalactosamine - Gotoh, M.; Yada, T.; Sato, T.; Akashima, T.; Iwasaki, H.; Mochizuki, H.; Inaba, N.; Togayachi, A.; Kudo, T.; Watanabe, H.; Kimata, K.; Narimatsu, H. (J Biol Chem, 2002)

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Fluid shear stress stimulates incorporation of hyaluronan into endothelial cell glycocalyx - Gouverneur, M.; Spaan, J. A.; Pannekoek, H.; Fontijn, R. D.; Vink, H. (Am J Physiol Heart Circ Physiol, 2006)

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Altered expression of chondroitin sulfate structure modifying sulfotransferases in thearticular cartilage from adult osteoarthritis and Kashin- Beck disease - Han, J.; Li, D.; Qu, C.; Wang, D.; Wang, L.; Guo, X.; Lammi, M. J. (Osteoarthr Cartil, 2017)

CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2 - Harada, H.; Takahashi, M. (J Biol Chem, 2007)

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The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc - Hascall, V. C.; Wang, A.; Tammi, M.; Oikari, S.; Tammi, R.; Passi, A.; Vigetti, D.; Hanson, R. W.; Hart, G. W. (Matrix Biol, 2014)

Overexpression of receptor for hyaluronan-mediated motility (RHAMM) in MC3T3-E1 cells induces proliferation and differentiation through phosphorylation of ERK1/2 - Hatano, H.; Shigeishi, H.; Kudo, Y.; Higashikawa, K.; Tobiume, K.; Takata, T.; Kamata, N. (J Bone Miner Metab, 2012)

CD44 is a determinant of inflammatory bone loss - Hayer, S.; Steiner, G.; Görtz, B.; Reiter, E.; Tohidast-Akrad, M.; Amling, M.; Hoffmann, O.; Redlich, K.; Zwerina, J.; Skriner, K.; Hilberg, F.; Wagner, E. F.; et al. (J Exp Med, 2005)

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Mechanical stretch induces epithelial-mesenchymal transition in alveolar epithelia via hyaluronan activation of innate immunity - Heise, R. L.; Stober, V.; Cheluvaraju, C.; Hollingsworth, J. W.; Garantziotis, S. (J Biol Chem, 2011)

Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human - Hiraoka, S.; Furuichi, T.; Nishimura, G.; Shibata, S.; Yanagishita, M.; Rimoin, D. L.; Superti-Furga, A.; Nikkels, P. G.; Ogawa, M.; Katsuyama, K.; Toyoda, H.; Kinoshita-Toyoda, A.; et al. (Nat Med, 2007)

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Identification of candidate synovial fluid biomarkers for the prediction of patient outcome after microfracture or osteotomy - Hulme, C. H.; Peffers, M. J.; Harrington, G. M. B.; Wilson, E.; Perry, J.; Roberts, S.; Gallacher, P.; Jermin, P.; Wright, K. T. (Am J Sports Med, 2021)

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Chondroitin sulfate N-acetylgalactosyltransferase-1 knockout shows milder phenotype in experimental autoimmune encephalomyelitis than in wild type - Inada, R.; Miyamoto, K.; Tanaka, N.; Moriguchi, K.; Kadomatsu, K.; Takeuchi, K.; Igarashi, M.; Kusunoki, S. (Glycobiology, 2021)

The cell surface hyaluronidase TMEM2 regulates cell adhesion and migration via degradation of hyaluronan at focal adhesion sites - Irie, F.; Tobisawa, Y.; Murao, A.; Yamamoto, H.; Ohyama, C.; Yamaguchi, Y. (J Biol Chem, 2021)

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N-acetylglucosamine 6-O-sulfotransferase-1-deficient mice show better functional recovery after spinal cord injury - Ito, Z.; Sakamoto, K.; Imagama, S.; Matsuyama, Y.; Zhang, H.; Hirano, K.; Ando, K.; Yamashita, T.; Ishiguro, N.; Kadomatsu, K. (J Neurosci, 2010)

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Skeletal and hematological anomalies in HYAL2-deficient mice: a second type of mucopolysaccharidosis IX? - Jadin, L.; Wu, X.; Ding, H.; Frost, G. I.; Onclinx, C.; Triggs-Raine, B.; Flamion, B. (FASEB J, 2008)

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Matrix-degrading protease ADAMTS-5 cleaves inter-α-inhibitor and releases active heavy chain 2 in synovial fluids from arthritic patients - Scavenius, C.; Poulsen, E. C.; Thøgersen, I. B.; Roebuck, M.; Frostick, S.; Bou-Gharios, G.; Yamamoto, K.; Deleuran, B.; Enghild, J. J. (J Biol Chem, 2019)

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Biosynthesis of the chondroitin sulfate proteoglycan. Purification and properties of xylosyltransferase - Stoolmiller, A. C.; Horwitz, A. L.; Dorfman, A. (J Biol Chem, 1972)

Simultaneous sulfation of endogenous chondroitin sulfate and chondroitin-derived oligosaccharides. Studies with separate 4-sulfating and 6-sulfating microsomal systems - Sugumaran, G.; Coburn, J. N.; Silbert, J. E. (J Biol Chem, 1986)

Effects of brefeldin A on the localization of chondroitin sulfate-synthesizing enzymes. Activities in subfractions of the Golgi from chick embryo epiphyseal cartilage - Sugumaran, G.; Katsman, M.; Silbert, J. E. (J Biol Chem, 1992)

TSG-6 protein is crucial for the development of pulmonary hyaluronan deposition, eosinophilia, and airway hyperresponsiveness in a murine model of asthma - Swaidani, S.; Cheng, G.; Lauer, M. E.; Sharma, M.; Mikecz, K.; Hascall, V. C.; Aronica, M. A. (J Biol Chem, 2013)

Role of hyaluronic acid in joint lubrication - Swann, D. A.; Radin, E. L.; Nazimiec, M.; Weisser, P. A.; Curran, N.; Lewinnek, G. (Ann Rheum Dis, 1974)

The formation of a stable complex between dissociated proteoglycan and hyaluronic acid in the absence of a link protein - Swann, D. A.; Powell, S.; Broadhurst, J.; Sordillo, E.; Sotman, S. (Biochem J, 1976)

Chondrocyte mechanotransduction: effects of compression on deformation of intracellular organelles and relevance to cellular biosynthesis - Szafranski, J. D.; Grodzinsky, A. J.; Burger, E.; Gaschen, V.; Hung, H. H.; Hunziker, E. B. (Osteoarthr Cartil, 2004)

Cyclic mechanical stretch augments hyaluronan production in cultured human uterine cervical fibroblast cells - Takemura, M.; Itoh, H.; Sagawa, N.; Yura, S.; Korita, D.; Kakui, K.; Kawamura, M.; Hirota, N.; Maeda, H.; Fujii, S. (Mol Hum Reprod, 2005)

Transcriptional and post-translational regulation of hyaluronan synthesis - Tammi, R. H.; Passi, A. G.; Rilla, K.; Karousou, E.; Vigetti, D.; Makkonen, K.; Tammi, M. I. (FEBS J, 2011)

The cell surface hyaluronidase TMEM2 is essential for systemic hyaluronan catabolism and turnover - Tobisawa, Y.; Fujita, N.; Yamamoto, H.; Ohyama, C.; Irie, F.; Yamaguchi, Y. (J Biol Chem, 2021)

Hyaluronan is not just a goo! - Toole, B. P. (J Clin Invest, 2000)

Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins - Tortorella, M. D.; Burn, T. C.; Pratta, M. A. (Science, 1999)

Biology of hyaluronan: insights from genetic disorders of hyaluronan metabolism - Triggs-Raine, B.; Natowicz, M. R. (World J Biol Chem, 2015)

Aggregation of cartilage proteoglycans - Tsiganos, C. P.; Hardingham, T. E.; Muir, H. (Biochem J, 1972)

Suppression of murine osteoarthritis by 4-methylumbelliferone - Tsuchiya, S.; Ohashi, Y.; Ishizuka, S.; Ishiguro, N.; O’Rourke, D. P.; Knudson, C. B.; Knudson, W. (J Orthop Res, 2020)

HYBID derived from tumor cells and tumor-associated macrophages contribute to the glioblastoma growth - Tsuji, S.; Nakamura, S.; Yamada, T.; Vega, S.; Okada, Y.; Inoue, S.; Shimazawa, M.; Hara, H. (Brain Res, 2021)

Signaling properties of hyaluronan receptors - Turley, E. A.; Noble, P. W.; Bourguignon, L. Y. (J Biol Chem, 2002)

Defferential effect of brefeldin A on the biosynthesis of heparan sulfate and chondroitin/dermatan sulfate proteoglycans in rat ovarian granulosa cells in culture - Uhlin-Hansen, L.; Yanagishita, M. (J Biol Chem, 1993)

Revisiting the Warburg effect: historical dogma versus current understanding - Vaupel, P.; Multhoff, G. (J Physiol, 2021)

Adamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor β1 (TGFβ1) signaling - Velasco, J.; Li, J.; DiPietro, L.; Stepp, M. A.; Sandy, J. D.; Plaas, A. (J Biol Chem, 2011)

Xylosylation is an endoplasmic reticulum to Golgi event - Vertel, B. M.; Walters, L. M.; Flay, N.; Kearns, A. E.; Schwartz, N. B. (J Biol Chem, 1993)

Age-related accumulation of the advanced glycation endproduct pentosidine in human articular cartilage aggrecan: the use of pentosidine levels as a quantitative measure of protein turnover - Verzijl, N.; DeGroot, J.; Bayliss, M. T.; Bijlsma, J. W.; Lafeber, F. P.; Maroudas, A.; TeKoppele, J. M. (Matrix Biol, 2001)

Investigating the elusive mechanism of glycosaminoglycan biosynthesis - Victor, X. V.; Nguyen, T. K.; Ethirajan, M.; Tran, V. M.; Nguyen, K. V.; Kuberan, B. (J Biol Chem, 2009)

Hyaluronan synthesis is inhibited by adenosine monophosphate-activated protein kinase through the regulation of HAS2 activity in human aortic smooth muscle cells - Vigetti, D.; Clerici, M.; Deleonibus, S.; Karousou, E.; Viola, M.; Moretto, P.; Heldin, P.; Hascall, V. C.; Luca, G.; Passi, A. (J Biol Chem, 2011)

Role of UDP-N-acetylglucosamine (GlcNAc) and O-GlcNAcylation of hyaluronan synthase 2 in the control of chondroitin sulfate and hyaluronan synthesis - Vigetti, D.; Deleonibus, S.; Moretto, P.; Karousou, E.; Viola, M.; Bartolini, B.; Hascall, V. C.; Tammi, M.; Luca, G.; Passi, A. (J Biol Chem, 2012)

Hyaluronan: biosynthesis and signaling - Vigetti, D.; Karousou, E.; Viola, M.; Deleonibus, S.; Luca, G.; Passi, A. (Biochim Biophys Acta, 2014)

The effects of glucosamine hydrochloride on subchondral bone changes in an animal model of osteoarthritis - Wang, S. X.; Laverty, S.; Dumitriu, M.; Plaas, A.; Grynpas, M. D. (Arthritis Rheum, 2007)

Hyaluronan matrices in pathobiological processes - Wang, A.; Motte, C.; Lauer, M.; Hascall, V. (FEBS J, 2011)

Murine tendon function is adversely affected by aggrecan accumulation due to the knockout of ADAMTS5 - Wang, V. M.; Bell, R. M.; Thakore, R.; Eyre, D. R.; Galante, J. O.; Li, J.; Sandy, J. D.; Plaas, A. (J Orthop Res, 2012)

Transcriptional activation of glucose transporter 1 in orthodontic tooth movement-associated mechanical response - Wang, Y.; Li, Q.; Liu, F.; Jin, S.; Zhang, Y.; Zhang, T.; Zhu, Y.; Zhou, Y. (Int J Oral Sci, 2018)

Shear stress regulation of endothelial glycocalyx structure is determined by glucobiosynthesis - Wang, G.; Kostidis, S.; Tiemeier, G. L.; Sol, W. M. P. J.; Vries, M. R.; Giera, M.; Carmeliet, P.; Berg, B. M.; Rabelink, T. J. (Arterioscler Thromb Vasc Biol, 2020)

Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development - Watanabe, Y.; Takeuchi, K.; Higa Onaga, S.; Sato, M.; Tsujita, M.; Abe, M.; Natsume, R.; Li, M.; Furuichi, T.; Saeki, M.; Izumikawa, T.; Hasegawa, A.; et al. (Biochem J, 2010)

Mechanobioreactors for cartilage tissue engineering - Weber, J. F.; Perez, R.; Waldman, S. D. (Methods Mol Biol, 2015)

Hyaluronan synthase: the mechanism of initiation at the reducing end and a Pendulum model for Polysaccharide Translocation to the cell exterior - Weigel, P. H. (Int J Cell Biol, 2015)

Discovery of the liver Hyaluronan Receptor for endocytosis (HARE) and its progressive emergence as the multi-ligand scavenger receptor Stabilin-2 - Weigel, P. H. (Biomolecules., 2019)

Hyaluronan synthases: a decade-plus of novel glycosyltransferases - Weigel, P. H.; DeAngelis, P. L. (J Biol Chem, 2007)

Characterization of the recombinant rat 175-kDa hyaluronan receptor for endocytosis (HARE) - Weigel, J. A.; Weigel, P. H. (J Biol Chem, 2003)

Hyaluronan synthases - Weigel, P. H.; Hascall, V. C.; Tammi, M. (J Biol Chem, 1997)

Sulphation heterogeneity in the trisaccharide (GalNAcSbeta1, 4GlcAbeta1, 3GalNAcS) isolated from the non-reducing terminal of human aggrecan chondroitin sulphate - West, L. A.; Roughley, P.; Nelson, F. R.; Plaas, A. H. (Biochem J, 1999)

Functional characterization of glucose transport in bovine articular chondrocytes - Windhaber, R. A.; Wilkins, R. J.; Meredith, D. (Pflugers Arch, 2003)

RHAMM induces progression of rheumatoid arthritis by enhancing the functions of fibroblast-like synoviocytes - Wu, J.; Qu, Y.; Zhang, Y. P.; Deng, J. X.; Yu, Q. H. (BMC Musculoskelet Disord, 2018)

Glycogenes in Oncofetal Chondroitin Sulfate biosynthesis are differently expressed and correlated with immune response in placenta and colorectal cancer - Wu, Z. Y.; He, Y. Q.; Wang, T. M.; Yang, D. W.; Li, D. H.; Deng, C. M.; Cao, L. J.; Zhang, J. B.; Xue, W. Q.; Jia, W. H. (Front Cell Dev Biol, 2021)

Distribution of lymphatic vessels in normal and arthritic human synovial tissues - Xu, H.; Edwards, J.; Banerji, S.; Prevo, R.; Jackson, D. G.; Athanasou, N. A. (Ann Rheum Dis, 2003)

Chondroitin sulfate synthase-2. Molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase which has dual enzymatic activities - Yada, T.; Gotoh, M.; Sato, T.; Shionyu, M.; Go, M.; Kaseyama, H.; Iwasaki, H.; Kikuchi, N.; Kwon, Y. D.; Togayachi, A.; Kudo, T.; Watanabe, H.; et al. (J Biol Chem, 2003)

A mammalian homolog of the zebrafish transmembrane protein 2 (TMEM2) is the long-sought-after cell-surface hyaluronidase - Yamamoto, H.; Tobisawa, Y.; Inubushi, T.; Irie, F.; Ohyama, C.; Yamaguchi, Y. (J Biol Chem, 2017)

In vivo survival strategies for cellular adaptation to hypoxia: HIF1α-dependent suppression of mitochondrial oxygen consumption and decrease of intracellular hypoxia are critical for survival of hypoxic chondrocytes - Yao, Q.; Parvez-Khan, M.; Schipani, E. (Bone, 2020)

Molecular heterogeneity of the SHAP-hyaluronan complex. Isolation and characterization of the complex in synovial fluid from patients with rheumatoid arthritis - Yingsung, W.; Zhuo, L.; Morgelin, M.; Yoneda, M.; Kida, D.; Watanabe, H.; Ishiguro, N.; Iwata, H.; Kimata, K. (J Biol Chem, 2003)

KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization - Yoshida, H.; Nagaoka, A.; Kusaka-Kikushima, A.; Tobiishi, M.; Kawabata, K.; Sayo, T.; Sakai, S.; Sugiyama, Y.; Enomoto, H.; Okada, Y.; Inoue, S. (Proc Natl Acad Sci U S A, 2013)

Murine homologue of the human KIAA1199 is implicated in hyaluronan binding and depolymerization - Yoshida, H.; Nagaoka, A.; Nakamura, S.; Sugiyama, Y.; Okada, Y.; Inoue, S. (FEBS Open Bio, 2013)

Superficial zone chondrocytes in normal and osteoarthritic human articular cartilages synthesize novel truncated forms of inter-alpha-trypsin inhibitor heavy chains which are attached to a chondroitin sulfate proteoglycan other than bikunin - Yoshihara, Y.; Plaas, A.; Osborn, B.; Margulis, A.; Nelson, F.; Stewart, M.; Rugg, M. S.; Milner, C. M.; Day, A. J.; Nemoto, K.; Sandy, J. D. (Osteoarthr Cartil, 2008)

Targeted deletion of HYBID (hyaluronan binding protein involved in hyaluronan depolymerization/KIAA1199/CEMIP) decreases dendritic spine density in the dentate gyrus through hyaluronan accumulation - Yoshino, Y.; Shimazawa, M.; Nakamura, S.; Inoue, S.; Yoshida, H.; Shimoda, M.; Okada, Y.; Hara, H. (Biochem Biophys Res Commun, 2018)

Induction of hyaluronan metabolism after mechanical injury of human peritoneal mesothelial cells in vitro - Yung, S.; Thomas, G. J.; Davies, M. (Kidney Int, 2000)

Mechanosensory and mechanotransductive processes mediated by ion channels in articular chondrocytes: Potential therapeutic targets for osteoarthritis - Zhang, K.; Wang, L.; Liu, Z.; Geng, B.; Teng, Y.; Liu, X.; Yi, Q.; Yu, D.; Chen, X.; Zhao, D.; Xia, Y. (Channels (Austin), 2021)

Secreted KIAA1199 promotes the progression of rheumatoid arthritis by mediating hyaluronic acid degradation in an ANXA1-dependent manner - Zhang, W.; Yin, G.; Zhao, H.; Ling, H.; Xie, Z.; Xiao, C.; Chen, Y.; Lin, Y.; Jiang, T.; Jin, S.; Wang, J.; Yang, X. (Cell Death Dis, 2021)

Evidence for the covalent binding of SHAP, heavy chains of inter-alpha-trypsin inhibitor, to hyaluronan - Zhao, M.; Yoneda, M.; Ohashi, Y.; Kurono, S.; Iwata, H.; Ohnuki, Y.; Kimata, K. (J Biol Chem, 1995)

The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis - Zheng, L.; Zhang, Z.; Sheng, P.; Mobasheri, A. (Ageing Res Rev, 2021)

Inter-alpha-trypsin inhibitor, a covalent protein-glycosaminoglycan-protein complex - Zhuo, L.; Hascall, V. C.; Kimata, K. (J Biol Chem, 2004)

Integration of sugar metabolism and proteoglycan synthesis by UDP-glucose dehydrogenase - Zimmer, B. M.; Barycki, J. J.; Simpson, M. A. (J Histochem Cytochem, 2021)